---
product_id: 253690400
title: "Methyl-Guard Plus - Active folate (5-MTHF) with Vitamins B2, B6, and B12 - Supports methylation and healthy level of homocysteine - Gluten-Free, Dairy-Free, Soy-Free - 90 Capsules"
brand: "thorne"
price: "$202"
currency: NZD
in_stock: true
reviews_count: 5
category: "Thorne"
url: https://www.desertcart.nz/products/253690400-methyl-guard-plus-active-folate-5-mthf-with-vitamins-b2
store_origin: NZ
region: New Zealand
---

# Tissue-ready B2, B6, B12 for superior absorption Active folate (5-MTHF) for optimal methylation Supports healthy homocysteine & cardiovascular health Methyl-Guard Plus - Active folate (5-MTHF) with Vitamins B2, B6, and B12 - Supports methylation and healthy level of homocysteine - Gluten-Free, Dairy-Free, Soy-Free - 90 Capsules

**Brand:** thorne
**Price:** $202
**Availability:** ✅ In Stock

## Summary

> 🧬 Elevate your wellness game with the methylation masterclass!

## Quick Answers

- **What is this?** Methyl-Guard Plus - Active folate (5-MTHF) with Vitamins B2, B6, and B12 - Supports methylation and healthy level of homocysteine - Gluten-Free, Dairy-Free, Soy-Free - 90 Capsules by thorne
- **How much does it cost?** $202 with free shipping
- **Is it available?** Yes, in stock and ready to ship
- **Where can I buy it?** [www.desertcart.nz](https://www.desertcart.nz/products/253690400-methyl-guard-plus-active-folate-5-mthf-with-vitamins-b2)

## Best For

- thorne enthusiasts

## Why This Product

- Trusted thorne brand quality
- Free international shipping included
- Worldwide delivery with tracking
- 15-day hassle-free returns

## Key Features

- • **Heart-Smart Formula:** Maintain healthy homocysteine levels to promote cardiovascular wellness and longevity.
- • **Trusted by Champions:** Backed by Mayo Clinic research and chosen by 100+ pro teams, including 11 U.S. Olympic teams.
- • **Bioavailable B-Vitamins:** Experience enhanced absorption with tissue-ready vitamins B2, B6, and B12 designed for maximum efficacy.
- • **Clean & Pure Confidence:** Gluten-free, dairy-free, soy-free, and free from common allergens—perfect for the mindful professional.
- • **Unlock Your Genetic Potential:** Harness the power of active folate (5-MTHF) to support efficient methylation and gene expression.

## Overview

THORNE Methyl-Guard Plus delivers active folate (5-MTHF) alongside bioavailable vitamins B2, B6, and B12 to support healthy methylation and maintain optimal homocysteine levels. This clean, allergen-free formula is trusted by elite athletes and backed by Mayo Clinic research, making it a top-tier choice for cardiovascular and genetic health support.

## Description

THORNE Methyl-Guard Plus - Active folate (5-MTHF) with Vitamins B2, B6, and B12 - Supports methylation and healthy level of homocysteine - Gluten-Free, Dairy-Free, Soy-Free - 90 Capsules : desertcart.ae: Automotive

Review: Excellent product for MTHFR genetic disorder
Review: High quality B complex! Helpful for MTHFR gene mutation. I have been using them for about six months now and notice a huge difference in my cycle regularity, as it has very high amounts of B6 and a methylated form, I’m convinced is due to this product. My menstrual cramps have all but almost completely disappeared, which is absolutely amazing considering I have struggled with that since my teens could not recommend this more, especially for women struggling with similar issues.

## Features

- Healthy Methylation: Methyl-Guard Plus supports methylation and promotes a healthy level of homocysteine
- Active Forms: Formulated with active folate (5-MTHF) and the active, tissue-ready forms of vitamins B2, B6, and B12 to optimize absorption
- Cardiovascular Support: Providing the nutritional cofactors for optimal homocysteine metabolism supports cardiovascular health
- Free From: Doesn't contain gluten, eggs, tree nuts, peanuts, dairy, soy, fish, or shellfish
- Trusted: Thorne is chosen by champions and trusted by 100+ pro teams. Thorne is the only supplement manufacturer to collaborate with Mayo Clinic on wellness research and content. Thorne is also a proud partner of 11 U.S. Olympic Teams

## Technical Specifications

| Specification | Value |
|---------------|-------|
| ASIN | B00O5AHC4S |
| ASIN  | B00O5AHC4S |
| Age Range Description | Adult |
| Best Sellers Rank | #1,914 in Health ( See Top 100 in Health ) #51 in Multivitamins Nutritional Supplements |
| Brand | THORNE |
| Customer Reviews | 4.7 4.7 out of 5 stars (2,623) |
| Customer reviews | 4.7 4.7 out of 5 stars (2,623) |
| Date First Available | 20 November 2012 |
| Format | Capsule |
| Is Discontinued By Manufacturer  | No |
| Item model number  | No Model |
| Manufacturer  | Thorne Research |
| Product Dimensions  | 6.05 x 6.05 x 10.74 cm; 108.86 g |
| Units | 2 Count |
| Weight | 0.24 Pounds |

## Product Details

- **Brand:** THORNE
- **Diet type:** Gluten Free
- **Flavour:** Unflavored
- **Item form:** Capsule
- **Primary supplement type:** Riboflavin

## Images

![Methyl-Guard Plus - Active folate (5-MTHF) with Vitamins B2, B6, and B12 - Supports methylation and healthy level of homocysteine - Gluten-Free, Dairy-Free, Soy-Free - 90 Capsules - Image 1](https://m.media-amazon.com/images/I/61BtsSBpN9L.jpg)

## Available Options

This product comes in different **Style** options.

## Questions & Answers

**Q: What is the difference between "methyl-guard" and "methyl-guard plus" products?**
A: Methyl Guard plus is stronger.  The Methyl Guard Plus contains about twice as much b12 (3mg vs 1.2mg), about twice as much folate (3mg vs 1.2mg), about twice as much b6 (45mg vs 20.4mg) and contains Riboflavin.

**Q: Why doesn't it show the label, I'm not going to pay this amount for something without knowing what and how much is in it!**
A: If you look at the selection of pictures to right of the bottle the bottom picture includes the label.  You can click on that image to show it larger.

**Q: are these capsules enteric coated? taking pyridoxal-5-phosphate without enteric coating useless**
A: Not coated. Just a vegetarian capsule. For me, my body has been starved of these active forms of B vitamins that it's anything but useless. If you want to encourage it not to digest as quickly, a trick my doctor tells me to do (with fish oil for example) is to freeze the capsule so that it takes longer to digest. You can look for the specific forms of active B vitamins to find them enteric coated. Details on the product: https://www.thorne.com/products/dp/methyl-guard-plus-reg

**Q: Does this turn your stools orange colored?**
A: Orange stools may signify you are dumping copper. Look up un bound copper, bioavailable copper and copper toxicity. You need boron and vit K2.

## Customer Reviews

### ⭐⭐⭐⭐⭐ Review
*by C***Y on 11 September 2025*

Excellent product for MTHFR genetic disorder

### ⭐⭐⭐⭐⭐ Review
*by J***N on 12 October 2025*

High quality B complex! Helpful for MTHFR gene mutation. I have been using them for about six months now and notice a huge difference in my cycle regularity, as it has very high amounts of B6 and a methylated form, I’m convinced is due to this product. My menstrual cramps have all but almost completely disappeared, which is absolutely amazing considering I have struggled with that since my teens could not recommend this more, especially for women struggling with similar issues.

### ⭐⭐⭐⭐⭐ Review
*by A***L on 4 August 2025*

I tell people that this is the first time I have ever felt a vitamin that I took. I have taken other B12 supplements in the past but this is the first one to significantly improve my B12 labs. It may seem expensive but I only take one a day so a bottle lasts me 6 months.

## Frequently Bought Together

- THORNE Methyl-Guard Plus - Active folate (5-MTHF) with Vitamins B2, B6 & B12 - Supports methylation & Healthy Level of homocysteine* - Gluten, Dairy & Soy-Free - 90 Capsules
- THORNE Magnesium CitraMate - Magnesium Supplement with Citrate-Malate - Support Heart, Skeletal Muscles, Cardiac, Lung Function, and Bone Density* - Gluten-Free, Dairy-Free, Soy-Free - 90 Capsules
- THORNE Vitamin D-5000 - Vitamin D3 Supplement - Support Healthy Bones, Teeth, Muscles, Cardiovascular, and Immune Function* - NSF Certified for Sport - Dairy-Free, Soy-Free - 60 Capsules

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---

*Product available on Desertcart New Zealand*
*Store origin: NZ*
*Last updated: 2026-02-21*